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Research Article

Paclitaxel Modulates TGFβ Signaling in Scleroderma Skin Grafts in Immunodeficient Mice

  • Xialin Liu equal contributor,

    equal contributor Contributed equally to this work with: Xialin Liu, Shoukang Zhu

    Affiliation: Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Shoukang Zhu equal contributor,

    equal contributor Contributed equally to this work with: Xialin Liu, Shoukang Zhu

    Affiliation: Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Tao Wang,

    Affiliation: Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Laura Hummers,

    Affiliation: Division of Rheumatology, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Fredrick M Wigley,

    Affiliation: Division of Rheumatology, Johns Hopkins University, Baltimore, Maryland, United States of America

    X
  • Pascal J Goldschmidt-Clermont,

    Affiliation: Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Chunming Dong mail

    To whom correspondence should be addressed. E-mail: dong0005@mc.duke.edu

    Affiliation: Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Published: November 01, 2005
  • DOI: 10.1371/journal.pmed.0020354

About the Authors

Xialin Liu, Shoukang Zhu, Tao Wang, Pascal J Goldschmidt-Clermont, Chunming Dong
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
Laura Hummers, Fredrick M Wigley
Division of Rheumatology, Johns Hopkins University, Baltimore, Maryland, United States of America

Corresponding Author

Email: dong0005@mc.duke.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CD had the original idea for the study, and designed and oversaw the study. XL and SZ performed most of the experimental procedures and data analysis and participated in the study design. TW performed some experiments. LH and FMW recruited the patients and collected the skin biopsies. PJGC helped develop the concept of the study, and coordinated and supervised the experiments. XL, PJGC, and CD contributed to the writing of the report.