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Research Article

A Malaria Vaccine That Elicits in Humans Antibodies Able to Kill Plasmodium falciparum

  • Pierre Druilhe mail,

    To whom correspondence should be addressed. E-mail: druilhe@pasteur.fr

    Affiliation: Biomedical Parasitology Unit, Pasteur Institute, Paris, France

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  • François Spertini,

    Affiliation: Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

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  • Daw Soesoe,

    Affiliation: Biomedical Parasitology Unit, Pasteur Institute, Paris, France

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  • Giampietro Corradin,

    Affiliation: Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland

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  • Pedro Mejia,

    Affiliation: Biomedical Parasitology Unit, Pasteur Institute, Paris, France

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  • Subhash Singh,

    Affiliation: Biomedical Parasitology Unit, Pasteur Institute, Paris, France

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  • Regine Audran,

    Affiliation: Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

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  • Ahmed Bouzidi,

    Affiliation: Sedac Therapeutics, Lille, France

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  • Claude Oeuvray,

    Affiliation: Biomedical Parasitology Unit, Pasteur Institute, Paris, France

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  • Christian Roussilhon

    Affiliation: Biomedical Parasitology Unit, Pasteur Institute, Paris, France

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  • Published: November 08, 2005
  • DOI: 10.1371/journal.pmed.0020344

About the Authors

Pierre Druilhe, Daw Soesoe, Pedro Mejia, Subhash Singh, Claude Oeuvray, Christian Roussilhon
Biomedical Parasitology Unit, Pasteur Institute, Paris, France
François Spertini, Regine Audran
Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Giampietro Corradin
Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
Ahmed Bouzidi
Sedac Therapeutics, Lille, France

Corresponding Author

Email: druilhe@pasteur.fr

Competing Interests

PD, DS, PM, SS, CO, and CR are affiliated with the Pasteur Institute, which holds a patent on merozoite surface protein 3.

Author Contributions

PD designed the study. DS, GC, PM, SS, and RA performed the biological experiments. PD, SS, RA, and CR analyzed the data. FS organized the clinical trial. AB and CO produced the vaccine. PD wrote the paper.