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Research Article

Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants

  • Heidi Greulich mail,

    To whom correspondence should be addressed. E-mail: heidig@broad.mit.edu (HG); E-mail: William_Sellers@dfci.harvard.edu (WRS); E-mail: Matthew_Meyerson@dfci.harvard.edu (MM)

    Affiliations: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • Tzu-Hsiu Chen,

    Affiliations: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • Whei Feng,

    Affiliations: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

    X
  • Pasi A Jänne,

    Affiliations: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • James V Alvarez,

    Affiliations: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Mauro Zappaterra,

    Affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Sara E Bulmer,

    Affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • David A Frank,

    Affiliations: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • William C Hahn,

    Affiliations: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • William R Sellers mail,

    To whom correspondence should be addressed. E-mail: heidig@broad.mit.edu (HG); E-mail: William_Sellers@dfci.harvard.edu (WRS); E-mail: Matthew_Meyerson@dfci.harvard.edu (MM)

    Affiliations: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

    X
  • Matthew Meyerson mail

    To whom correspondence should be addressed. E-mail: heidig@broad.mit.edu (HG); E-mail: William_Sellers@dfci.harvard.edu (WRS); E-mail: Matthew_Meyerson@dfci.harvard.edu (MM)

    Affiliations: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: October 04, 2005
  • DOI: 10.1371/journal.pmed.0020313

About the Authors

Heidi Greulich, Tzu-Hsiu Chen, Whei Feng, Pasi A Jänne, James V Alvarez, Mauro Zappaterra, Sara E Bulmer, David A Frank, William C Hahn, William R Sellers, Matthew Meyerson
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
Heidi Greulich, Pasi A Jänne, James V Alvarez, David A Frank, William C Hahn, William R Sellers
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
Heidi Greulich, Tzu-Hsiu Chen, Whei Feng, William C Hahn, William R Sellers, Matthew Meyerson
The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
William C Hahn, Matthew Meyerson
Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

HG, THC, WF, JVA, MZ, SEB, DAF, WCH, WRS, and MM designed and executed the study. HG, PJ, WCH, WRS, and MM contributed to writing the paper.