Advertisement
Research Article

A C1173T Dimorphism in the VKORC1 Gene Determines Coumarin Sensitivity and Bleeding Risk

  • Pieter H Reitsma mail,

    To whom correspondence should be addressed. E-mail: p.h.reitsma@amc.uva.nl

    Affiliation: Laboratory for Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    X
  • Jeroen F. van der Heijden,

    Affiliation: Laboratory for Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    X
  • Angelique P Groot,

    Affiliation: Laboratory for Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    X
  • Frits R Rosendaal,

    Affiliation: Departments of Clinical Epidemiology and Hematology, Leiden University Medical Center, Leiden, The Netherlands

    X
  • Harry R Büller

    Affiliation: Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    X
  • Published: October 11, 2005
  • DOI: 10.1371/journal.pmed.0020312

About the Authors

Pieter H Reitsma, Jeroen F. van der Heijden, Angelique P Groot
Laboratory for Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Frits R Rosendaal
Departments of Clinical Epidemiology and Hematology, Leiden University Medical Center, Leiden, The Netherlands
Harry R Büller
Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Corresponding Author

Email: p.h.reitsma@amc.uva.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

PHR and HRB designed the study. PHR drafted the report and incorporated all suggestions. JFV was responsible for collecting all patient data and specimens. APG drafted the genetic assay and performed the lab analyses. FRR oversaw the statistical analyses and other methodological issues of the report.