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Research Article

Up-Regulation and Profibrotic Role of Osteopontin in Human Idiopathic Pulmonary Fibrosis

  • Annie Pardo,

    Affiliation: Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City, Mexico

    X
  • Kevin Gibson,

    Affiliation: The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, Pulmonary Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • José Cisneros,

    Affiliation: Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico

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  • Thomas J Richards,

    Affiliation: The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, Pulmonary Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Yinke Yang,

    Affiliation: The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, Pulmonary Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Carina Becerril,

    Affiliation: Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico

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  • Samueal Yousem,

    Affiliation: Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Iliana Herrera,

    Affiliation: Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City, Mexico

    X
  • Victor Ruiz,

    Affiliation: Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico

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  • Moisés Selman,

    Affiliation: Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico

    X
  • Naftali Kaminski mail

    To whom correspondence should be addressed. E-mail: kaminskin@upmc.edu

    Affiliation: The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, Pulmonary Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Published: September 06, 2005
  • DOI: 10.1371/journal.pmed.0020251

About the Authors

Annie Pardo, Iliana Herrera
Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City, Mexico
Kevin Gibson, Thomas J Richards, Yinke Yang, Naftali Kaminski
The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, Pulmonary Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
José Cisneros, Carina Becerril, Victor Ruiz, Moisés Selman
Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico
Samueal Yousem
Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Corresponding Author

Email: kaminskin@upmc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AP, KG, SY, VR, MS, and NK designed the study. KG, JC, TJR, YY, CB, IH, VR, and NK performed experiments. AP, KG, JC, YY, SY, IH, VR, MS, and NK analyzed the data. AP, KG, MS, and NK enrolled patients. AP, KG, MS, and NK contributed to writing the paper.