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Research Article

Decreased Insulin-Stimulated ATP Synthesis and Phosphate Transport in Muscle of Insulin-Resistant Offspring of Type 2 Diabetic Parents

  • Kitt F Petersen,

    Affiliation: Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Sylvie Dufour,

    Affiliations: Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Gerald I Shulman

    Affiliations: Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, United States of America, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Published: August 16, 2005
  • DOI: 10.1371/journal.pmed.0020233

About the Authors

Kitt F Petersen, Sylvie Dufour, Gerald I Shulman
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
Gerald I Shulman
Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, United States of America
Sylvie Dufour, Gerald I Shulman
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, United States of America

Competing Interests

The authors have declared that no competing interests exist. GIS is a member of the editorial board of PLOS Medicine.

Author Contributions

KFP, SD, and GIS designed the study and analyzed the data. KFP enrolled patients. KFP, SD, and GIS contributed to writing the paper.