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Research Article

Dissection of the Inflammatory Bowel Disease Transcriptome Using Genome-Wide cDNA Microarrays

  • Christine M Costello,

    Affiliation: Institute for Clinical Molecular Biology, University Hospital Schleswig Holstein, Christian-Albrechts University of Kiel, Kiel, Germany

    ¤a Current address: The Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Ireland

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  • Nancy Mah,

    Affiliation: Institute for Clinical Molecular Biology, University Hospital Schleswig Holstein, Christian-Albrechts University of Kiel, Kiel, Germany

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  • Robert Häsler,

    Affiliation: Institute for Clinical Molecular Biology, University Hospital Schleswig Holstein, Christian-Albrechts University of Kiel, Kiel, Germany

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  • Philip Rosenstiel,

    Affiliation: Institute for Clinical Molecular Biology, University Hospital Schleswig Holstein, Christian-Albrechts University of Kiel, Kiel, Germany

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  • Georg H Waetzig,

    Affiliation: CONARIS Research Institute, Kiel, Germany

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  • Andreas Hahn,

    Affiliation: Department of Computational Biology and Applied Algorithmics, Max-Planck-Institute for Informatics, Saarbrücken, Germany

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  • Tim Lu,

    Affiliation: Institute for Clinical Molecular Biology, University Hospital Schleswig Holstein, Christian-Albrechts University of Kiel, Kiel, Germany

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  • Yesim Gurbuz,

    Affiliation: Institute of Pathology, University Hospital Schleswig Holstein, Kiel, Germany

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  • Susanna Nikolaus,

    Affiliation: Department of General Internal Medicine, University Hospital Schleswig Holstein, Kiel, Germany

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  • Mario Albrecht,

    Affiliation: Department of Computational Biology and Applied Algorithmics, Max-Planck-Institute for Informatics, Saarbrücken, Germany

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  • Jochen Hampe,

    Affiliation: Institute for Clinical Molecular Biology, University Hospital Schleswig Holstein, Christian-Albrechts University of Kiel, Kiel, Germany

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  • Ralph Lucius,

    Affiliation: Institute of Anatomy, University Hospital Schleswig Holstein, Kiel, Germany

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  • Günther Klöppel,

    Affiliation: Institute of Pathology, University Hospital Schleswig Holstein, Kiel, Germany

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  • Holger Eickhoff,

    Affiliation: Max-Planck-Institute for Molecular Genetics, Berlin, Germany

    ¤b Current address: Scienion, Berlin, Germany

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  • Hans Lehrach,

    Affiliation: Max-Planck-Institute for Molecular Genetics, Berlin, Germany

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  • Thomas Lengauer,

    Affiliation: Department of Computational Biology and Applied Algorithmics, Max-Planck-Institute for Informatics, Saarbrücken, Germany

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  • Stefan Schreiber mail

    To whom correspondence should be addressed. E-mail: s.schreiber@mucosa.de

    Affiliation: Institute for Clinical Molecular Biology, University Hospital Schleswig Holstein, Christian-Albrechts University of Kiel, Kiel, Germany

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  • Published: August 23, 2005
  • DOI: 10.1371/journal.pmed.0020199

About the Authors

Christine M Costello, Nancy Mah, Robert Häsler, Philip Rosenstiel, Tim Lu, Jochen Hampe, Stefan Schreiber
Institute for Clinical Molecular Biology, University Hospital Schleswig Holstein, Christian-Albrechts University of Kiel, Kiel, Germany
Georg H Waetzig
CONARIS Research Institute, Kiel, Germany
Andreas Hahn, Mario Albrecht, Thomas Lengauer
Department of Computational Biology and Applied Algorithmics, Max-Planck-Institute for Informatics, Saarbrücken, Germany
Yesim Gurbuz, Günther Klöppel
Institute of Pathology, University Hospital Schleswig Holstein, Kiel, Germany
Susanna Nikolaus
Department of General Internal Medicine, University Hospital Schleswig Holstein, Kiel, Germany
Ralph Lucius
Institute of Anatomy, University Hospital Schleswig Holstein, Kiel, Germany
Holger Eickhoff, Hans Lehrach
Max-Planck-Institute for Molecular Genetics, Berlin, Germany

Corresponding Author

Email: s.schreiber@mucosa.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CMC, JH, and SS designed the study. SN and SS enrolled patients. HE and HL developed microarray methodologies. CMC, NM, PR, GHW, and RL carried out experiments/acquired data. PR, SN, YG, and GK acquired patient data. CMC, NM, RH, AH, TL, MA, and TL analyzed the data. CMC is the principle author of this manuscript, while NM, RH, PR, and SS contributed to writing the paper.