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Research Article

An Immune Basis for Malaria Protection by the Sickle Cell Trait

  • Thomas N Williams mail,

    To whom correspondence should be addressed. E-mail: twilliams@ kilifi.mimcom.net

    Affiliations: Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom, Department of Paediatrics, John Radcliffe Hospital, Oxford, United Kingdom

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  • Tabitha W Mwangi,

    Affiliation: Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya

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  • David J Roberts,

    Affiliations: Blood Research Laboratory, National Blood Service—Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, United Kingdom

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  • Neal D Alexander,

    Affiliation: Medical Research Council Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • David J Weatherall,

    Affiliation: Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom

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  • Sammy Wambua,

    Affiliation: Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya

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  • Moses Kortok,

    Affiliation: Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya

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  • Robert W Snow,

    Affiliations: Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom

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  • Kevin Marsh

    Affiliations: Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom

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  • Published: May 31, 2005
  • DOI: 10.1371/journal.pmed.0020128

About the Authors

Thomas N Williams, Tabitha W Mwangi, Sammy Wambua, Moses Kortok, Robert W Snow, Kevin Marsh
Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya
Thomas N Williams, Robert W Snow, Kevin Marsh
Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom
Thomas N Williams
Department of Paediatrics, John Radcliffe Hospital, Oxford, United Kingdom
David J Roberts
Blood Research Laboratory, National Blood Service—Oxford, John Radcliffe Hospital, Oxford, United Kingdom
David J Roberts
Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, United Kingdom
Neal D Alexander
Medical Research Council Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, United Kingdom
David J Weatherall
Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom

Corresponding Author

Email: twilliams@ kilifi.mimcom.net

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

TNW, TWM, DJR, DJW, and KM designed the study. TNW, NDA, SW, and MK analyzed the data. TNW wrote the paper.