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Research Article

SARS Transmission Pattern in Singapore Reassessed by Viral Sequence Variation Analysis

  • Jianjun Liu mail,

    To whom correspondence should be addressed. E-mail: liuj3@gis.a-star.edu.sg

    Affiliation: Genome Institute of Singapore, Singapore, Singapore

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  • Siew Lan Lim,

    Affiliation: Genome Institute of Singapore, Singapore, Singapore

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  • Yijun Ruan,

    Affiliation: Genome Institute of Singapore, Singapore, Singapore

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  • Ai Ee Ling,

    Affiliation: Department of Pathology, Singapore General Hospital, Singapore

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  • Lisa F. P Ng,

    Affiliation: Genome Institute of Singapore, Singapore, Singapore

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  • Christian Drosten,

    Affiliation: Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases, Hamburg, Germany

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  • Edison T Liu,

    Affiliation: Genome Institute of Singapore, Singapore, Singapore

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  • Lawrence W Stanton,

    Affiliation: Genome Institute of Singapore, Singapore, Singapore

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  • Martin L Hibberd

    Affiliation: Genome Institute of Singapore, Singapore, Singapore

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  • Published: February 22, 2005
  • DOI: 10.1371/journal.pmed.0020043

About the Authors

Jianjun Liu, Siew Lan Lim, Yijun Ruan, Lisa F. P Ng, Edison T Liu, Lawrence W Stanton, Martin L Hibberd
Genome Institute of Singapore, Singapore, Singapore
Ai Ee Ling
Department of Pathology, Singapore General Hospital, Singapore
Christian Drosten
Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases, Hamburg, Germany

Corresponding Author

Email: liuj3@gis.a-star.edu.sg

Competing Interests

The authors have declared that no competing interests exist. ETL is a member of the Editorial Board of PLOS Medicine.

Author Contributions

JL, ETL, LWS, and MLH designed the study. JL, SLL, and CD analyzed the data. LFPN performed the experiments. YR coordinated sample acquiring and provided the genome sequence variation data for designing MS assays. AEL provided SARS-CoV samples from patients. JL, SLL, YR, AEL, LFPN, CD, ETL, LWS, and MLH contributed to writing the paper.