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Research Article

Modulation of Statin-Activated Shedding of Alzheimer APP Ectodomain by ROCK

  • Steve Pedrini equal contributor,

    equal contributor Contributed equally to this work with: Steve Pedrini, Troy L Carter

    Affiliation: Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Troy L Carter equal contributor,

    equal contributor Contributed equally to this work with: Steve Pedrini, Troy L Carter

    Affiliation: Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • George Prendergast,

    Affiliation: Lankenau Institute for Medical Research, Wynnewood, Pennsylvania, United States of America

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  • Suzana Petanceska,

    Affiliation: Nathan S. Kline Institute for Psychiatric Research, Department of Psychiatry, New York University School of Medicine, Orangeburg, New York, United States of America

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  • Michelle E Ehrlich,

    Affiliation: Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Sam Gandy

    Affiliations: Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, Lankenau Institute for Medical Research, Wynnewood, Pennsylvania, United States of America

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  • Published: January 11, 2005
  • DOI: 10.1371/journal.pmed.0020018

About the Authors

Steve Pedrini, Troy L Carter, Michelle E Ehrlich, Sam Gandy
Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
George Prendergast, Sam Gandy
Lankenau Institute for Medical Research, Wynnewood, Pennsylvania, United States of America
Suzana Petanceska
Nathan S. Kline Institute for Psychiatric Research, Department of Psychiatry, New York University School of Medicine, Orangeburg, New York, United States of America

Corresponding Author

Email: samgandy@earthlink.net

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

SP, TC, GP, SP, MEE, and SG designed the study, analyzed the data, and contributed to writing the paper.