Advertisement
Research Article

Are Anticapsular Antibodies the Primary Mechanism of Protection against Invasive Pneumococcal Disease?

  • Marc Lipsitch mail,

    To whom correspondence should be addressed. E-mail: mlipsitc@hsph.harvard.edu

    Affiliation: Departments of Epidemiology and Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

    X
  • Cynthia G Whitney,

    Affiliation: Active Bacterial Core Surveillance and Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Elizabeth Zell,

    Affiliation: Active Bacterial Core Surveillance and Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Tarja Kaijalainen,

    Affiliation: National Reference Laboratory for Pneumococcus, National Public Health Institute, Oulu, Finland

    X
  • Ron Dagan,

    Affiliation: Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

    X
  • Richard Malley

    Affiliation: Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Published: January 25, 2005
  • DOI: 10.1371/journal.pmed.0020015

About the Authors

Marc Lipsitch
Departments of Epidemiology and Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
Cynthia G Whitney, Elizabeth Zell
Active Bacterial Core Surveillance and Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
Tarja Kaijalainen
National Reference Laboratory for Pneumococcus, National Public Health Institute, Oulu, Finland
Ron Dagan
Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Richard Malley
Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: mlipsitc@hsph.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ML and RM designed the study. TK and RD conducted the studies. ML and EZ analyzed the data. CGW, EZ, and the Active Bacterial Core Surveillance Team contributed reagents/materials/analysis tools. ML, RM, CGW, and RD contributed to writing the paper. The members of the Active Bacterial Core Surveillance Team are listed in the Acknowledgments.