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Research Article

Cancer as a Complex Phenotype: Pattern of Cancer Distribution within and beyond the Nuclear Family

  • Laufey T Amundadottir mail,

    To whom correspondence should be addressed. E-mail: laufey.amundadottir@decode.is (LTA), E-mail: kari.stefansson@decode.is (KS)

    Affiliation: deCODE Genetics, Reykjavik, Iceland

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  • Sverrir Thorvaldsson,

    Affiliation: deCODE Genetics, Reykjavik, Iceland

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  • Daniel F Gudbjartsson,

    Affiliation: deCODE Genetics, Reykjavik, Iceland

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  • Patrick Sulem,

    Affiliation: deCODE Genetics, Reykjavik, Iceland

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  • Kristleifur Kristjansson,

    Affiliation: deCODE Genetics, Reykjavik, Iceland

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  • Sigurdur Arnason,

    Affiliation: deCODE Genetics, Reykjavik, Iceland

    ¤1Current address: Keflavik County Hospital, Keflavik, Iceland

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  • Jeffrey R Gulcher,

    Affiliation: deCODE Genetics, Reykjavik, Iceland

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  • Johannes Bjornsson,

    Affiliation: National University Hospital, Reykjavik, Iceland

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  • Augustine Kong,

    Affiliation: deCODE Genetics, Reykjavik, Iceland

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  • Unnur Thorsteinsdottir,

    Affiliation: deCODE Genetics, Reykjavik, Iceland

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  • Kari Stefansson

    Affiliation: deCODE Genetics, Reykjavik, Iceland

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  • Published: December 28, 2004
  • DOI: 10.1371/journal.pmed.0010065

About the Authors

Laufey T Amundadottir, Sverrir Thorvaldsson, Daniel F Gudbjartsson, Patrick Sulem, Kristleifur Kristjansson, Sigurdur Arnason, Jeffrey R Gulcher, Augustine Kong, Unnur Thorsteinsdottir, Kari Stefansson
deCODE Genetics, Reykjavik, Iceland
Johannes Bjornsson
National University Hospital, Reykjavik, Iceland

Corresponding Authors

Competing Interests

JB and SA have declared that no competing interests exist. LTA, ST, DFG, PS, KK, JRG, AK, UT, KS have stock in deCODE Genetics as well as equity interests.

Author Contributions

LTA, ST, DFG, PS, KK, SA, JRG, JB, AK, UT, and KS designed the study. LTA, ST, DFG, PS, AK, and UT analyzed the data. LTA, ST, DFG, PS, KK, SA, JRG, JB, AK, UT, and KS contributed to writing the paper.