Advertisement
Research Article

An Inflammatory Cascade Leading to Hyperresistinemia in Humans

  • Michael Lehrke equal contributor,

    equal contributor Contributed equally to this work with: Michael Lehrke, Muredach P Reilly

    Affiliation: Divisions of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Muredach P Reilly equal contributor,

    equal contributor Contributed equally to this work with: Michael Lehrke, Muredach P Reilly

    Affiliations: Cardiology Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Experimental Therapeutics and Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Segan C Millington,

    Affiliation: Divisions of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Nayyar Iqbal,

    Affiliation: Divisions of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Daniel J Rader,

    Affiliations: Cardiology Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Experimental Therapeutics and Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Mitchell A Lazar

    Affiliation: Divisions of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Published: November 30, 2004
  • DOI: 10.1371/journal.pmed.0010045

About the Authors

Michael Lehrke, Segan C Millington, Nayyar Iqbal, Mitchell A Lazar
Divisions of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
Muredach P Reilly, Daniel J Rader
Cardiology Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
Muredach P Reilly, Daniel J Rader
Center for Experimental Therapeutics and Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: lazar@mail.med.upenn.edu

Competing Interests

MPR has received research funding or honoraria from GlaxoSmithKline, Merck, Ely Lilly, and KOS Pharmaceuticals. MAL has received a research grant from GlaxoSmithKline and has a United States patent application pending for therapeutic antagonism of human resistin. MAL and the University of Pennsylvania have licensed to Linco the monoclonal antibodies used in the human resistin assay.

Author Contributions

ML, MPR, NI, DJR, and MAL designed the study. ML, MPR, and SCM performed experiments. ML, MPR, NI, and MAL analyzed the data. MPR and NI enrolled patients. ML, MPR, NI, DJR, and MAL contributed to writing the paper. MAL obtained funding for the study and provided the research environment where the studies were conducted.