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Research Article

Assessment of Volume Depletion in Children with Malaria

  • Timothy Planche,

    Affiliations: Department of Cellular and Molecular Medicine, Infectious Diseases, St. George's Hospital Medical School, London, United Kingdom, Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon

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  • Myriam Onanga,

    Affiliation: Département de Parasitologie, Mycologie, et Médecine Tropicale, Faculté de Médecine, Université des Sciences de la Santé, Libreville, Gabon

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  • Achim Schwenk,

    Affiliations: Department of Cellular and Molecular Medicine, Infectious Diseases, St. George's Hospital Medical School, London, United Kingdom, Coleridge Unit, North Middlesex University Hospital, London, United Kingdom

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  • Arnaud Dzeing,

    Affiliation: Département de Parasitologie, Mycologie, et Médecine Tropicale, Faculté de Médecine, Université des Sciences de la Santé, Libreville, Gabon

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  • Steffen Borrmann,

    Affiliations: Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon, Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany

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  • Jean-François Faucher,

    Affiliation: Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon

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  • Antony Wright,

    Affiliation: Elsie Widdowson Laboratory, Medical Research Council Human Nutrition Research, Cambridge, United Kingdom

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  • Les Bluck,

    Affiliation: Elsie Widdowson Laboratory, Medical Research Council Human Nutrition Research, Cambridge, United Kingdom

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  • Leigh Ward,

    Affiliation: Department of Biochemistry, University of Queensland, St Lucia, Australia

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  • Maryvonne Kombila,

    Affiliation: Département de Parasitologie, Mycologie, et Médecine Tropicale, Faculté de Médecine, Université des Sciences de la Santé, Libreville, Gabon

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  • Peter G Kremsner,

    Affiliations: Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon, Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany

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  • Sanjeev Krishna

    Affiliations: Department of Cellular and Molecular Medicine, Infectious Diseases, St. George's Hospital Medical School, London, United Kingdom, Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon

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  • Published: October 19, 2004
  • DOI: 10.1371/journal.pmed.0010018

About the Authors

Timothy Planche, Achim Schwenk, Sanjeev Krishna
Department of Cellular and Molecular Medicine, Infectious Diseases, St. George's Hospital Medical School, London, United Kingdom
Timothy Planche, Steffen Borrmann, Jean-François Faucher, Peter G Kremsner, Sanjeev Krishna
Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon
Myriam Onanga, Arnaud Dzeing, Maryvonne Kombila
Département de Parasitologie, Mycologie, et Médecine Tropicale, Faculté de Médecine, Université des Sciences de la Santé, Libreville, Gabon
Achim Schwenk
Coleridge Unit, North Middlesex University Hospital, London, United Kingdom
Steffen Borrmann, Peter G Kremsner
Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany
Leigh Ward
Department of Biochemistry, University of Queensland, St Lucia, Australia
Antony Wright, Les Bluck
Elsie Widdowson Laboratory, Medical Research Council Human Nutrition Research, Cambridge, United Kingdom

Corresponding Author

Email: s.krishna@sghms.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

TP, MK, JFF, MO, PGK, and SK designed the study. TP, SB, and AD analysed patient data; AS analysed the BIA data and constructed the models; AW and LB conducted the analysis of heavy water; and LW analysed the bromide data. TP and SK wrote the first draft of the paper; all authors commented extensively on subsequent drafts.