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Research Article

Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration

  • Irving Kirsch mail,

    To whom correspondence should be addressed. E-mail: i.kirsch@hull.ac.uk

    Affiliation: Department of Psychology, University of Hull, Hull, United Kingdom

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  • Brett J Deacon,

    Affiliation: University of Wyoming, Laramie, Wyoming, United States of America

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  • Tania B Huedo-Medina,

    Affiliation: Center for Health, Intervention, and Prevention, University of Connecticut, Storrs, Connecticut, United States of America

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  • Alan Scoboria,

    Affiliation: Department of Psychology, University of Windsor, Windsor, Ontario, Canada

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  • Thomas J Moore,

    Affiliation: Institute for Safe Medication Practices, Huntingdon Valley, Pennsylvania, United States of America

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  • Blair T Johnson

    Affiliation: Center for Health, Intervention, and Prevention, University of Connecticut, Storrs, Connecticut, United States of America

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  • Published: February 26, 2008
  • DOI: 10.1371/journal.pmed.0050045

Reader Comments (48)

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translate to practice

Posted by plosmedicine on 31 Mar 2009 at 00:27 GMT

Author: Gail Reiner
Position: FNP
Institution: Minute clinic
E-mail: gehanscom@cox.net
Submitted Date: June 10, 2008
Published Date: June 11, 2008
This comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.

Given the overuse of antidepressants for children and adults with consequent side-effects in many cases, this article is refreshing and should have immediate impact on clinical practice.

No competing interests declared.