Advertisement
Research Article

Streptococcal Toxic Shock Syndrome Caused by Streptococcus suis Serotype 2

  • Jiaqi Tang equal contributor mail,

    equal contributor Contributed equally to this work with: Jiaqi Tang, Changjun Wang, Youjun Feng, Weizhong Yang, Huaidong Song, Zhihai Chen, Hongjie Yu

    To whom correspondence should be addressed. E-mail: gaof@im.ac.cn (GFG), E-mail: tjq85@hotmail.com (JT), E-mail: xnwang@21cn.net (XW), E-mail: wangyu@chinacdc.net.cn (YW).

    Affiliation: Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China

    X
  • Changjun Wang equal contributor,

    equal contributor Contributed equally to this work with: Jiaqi Tang, Changjun Wang, Youjun Feng, Weizhong Yang, Huaidong Song, Zhihai Chen, Hongjie Yu

    Affiliation: Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China

    X
  • Youjun Feng equal contributor,

    equal contributor Contributed equally to this work with: Jiaqi Tang, Changjun Wang, Youjun Feng, Weizhong Yang, Huaidong Song, Zhihai Chen, Hongjie Yu

    Affiliations: Center for Molecular Immunology and State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, Graduate School, Chinese Academy of Sciences, Beijing, China

    X
  • Weizhong Yang equal contributor,

    equal contributor Contributed equally to this work with: Jiaqi Tang, Changjun Wang, Youjun Feng, Weizhong Yang, Huaidong Song, Zhihai Chen, Hongjie Yu

    Affiliation: Chinese Center for Disease Control and Prevention (China CDC), Beijing, China

    X
  • Huaidong Song equal contributor,

    equal contributor Contributed equally to this work with: Jiaqi Tang, Changjun Wang, Youjun Feng, Weizhong Yang, Huaidong Song, Zhihai Chen, Hongjie Yu

    Affiliations: State Key Laboratory of Medical Genomics, Ruijin Hospital Affiliated to Medical School of Shanghai Jiao-Tong University, Shanghai, China, Chinese National Human Genome Center, Shanghai, China

    X
  • Zhihai Chen equal contributor,

    equal contributor Contributed equally to this work with: Jiaqi Tang, Changjun Wang, Youjun Feng, Weizhong Yang, Huaidong Song, Zhihai Chen, Hongjie Yu

    Affiliation: Beijing Ditan Hospital, Beijing, China

    X
  • Hongjie Yu equal contributor,

    equal contributor Contributed equally to this work with: Jiaqi Tang, Changjun Wang, Youjun Feng, Weizhong Yang, Huaidong Song, Zhihai Chen, Hongjie Yu

    Affiliation: Chinese Center for Disease Control and Prevention (China CDC), Beijing, China

    X
  • Xiuzhen Pan,

    Affiliation: Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China

    X
  • Xiaojun Zhou,

    Affiliation: Department of Pathology, Jinling Hospital of Nanjing, Nanjing, China

    X
  • Huaru Wang,

    Affiliation: Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China

    X
  • Bo Wu,

    Affiliation: Department of Pathology, Jinling Hospital of Nanjing, Nanjing, China

    X
  • Haili Wang,

    Affiliation: Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China

    X
  • Huamei Zhao,

    Affiliation: Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China

    X
  • Ying Lin,

    Affiliation: School of Biosciences and Bioengineering, South China University of Technology, Guangzhou, China

    X
  • Jianhua Yue,

    Affiliation: Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China

    X
  • Zhenqiang Wu,

    Affiliation: School of Biosciences and Bioengineering, South China University of Technology, Guangzhou, China

    X
  • Xiaowei He,

    Affiliation: School of Biosciences and Bioengineering, South China University of Technology, Guangzhou, China

    X
  • Feng Gao,

    Affiliation: Center for Molecular Immunology and State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

    X
  • Abdul Hamid Khan,

    Affiliations: Center for Molecular Immunology and State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, Graduate School, Chinese Academy of Sciences, Beijing, China

    X
  • Jian Wang,

    Affiliation: Beijing Genomics Institute, Chinese Academy of Sciences, Beijing, China

    X
  • Guo-Ping Zhao,

    Affiliation: Chinese National Human Genome Center, Shanghai, China

    X
  • Yu Wang mail,

    To whom correspondence should be addressed. E-mail: gaof@im.ac.cn (GFG), E-mail: tjq85@hotmail.com (JT), E-mail: xnwang@21cn.net (XW), E-mail: wangyu@chinacdc.net.cn (YW).

    Affiliation: Chinese Center for Disease Control and Prevention (China CDC), Beijing, China

    X
  • Xiaoning Wang mail,

    To whom correspondence should be addressed. E-mail: gaof@im.ac.cn (GFG), E-mail: tjq85@hotmail.com (JT), E-mail: xnwang@21cn.net (XW), E-mail: wangyu@chinacdc.net.cn (YW).

    Affiliation: School of Biosciences and Bioengineering, South China University of Technology, Guangzhou, China

    X
  • Zhu Chen,

    Affiliations: State Key Laboratory of Medical Genomics, Ruijin Hospital Affiliated to Medical School of Shanghai Jiao-Tong University, Shanghai, China, Chinese National Human Genome Center, Shanghai, China

    X
  • George F Gao mail

    To whom correspondence should be addressed. E-mail: gaof@im.ac.cn (GFG), E-mail: tjq85@hotmail.com (JT), E-mail: xnwang@21cn.net (XW), E-mail: wangyu@chinacdc.net.cn (YW).

    Affiliation: Center for Molecular Immunology and State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

    X
  • Published: April 11, 2006
  • DOI: 10.1371/journal.pmed.0030151

Reader Comments (2)

Post a new comment on this article

Capsular polysaccharide synthesis gene cluster- what’s correct?--the figures

Posted by lixuerui2002 on 13 Jan 2010 at 01:56 GMT

red by the
S. suis 2 isolates from China. Five of 12 structural genes, including
cps2B, cps2D, cps2F, cps2K, and
cps2L exactly matched those of
S. suis P1/7. In contrast, seven structural genes showed some point variations. The divergent genes included
cps2A (G163A, F273I, and F302L),
cps2C (I160V and Q195K),
cps2E (G190E, W264L, and S281C),
cps2G (F183Y),

http://plosmedicine.org/article/info:doi/10.1371/journal.pmed.0030151#article1.body1.sec3.sec6.p1


Figure 1 Comparison of the cps2 Gene Clusters Involved in CPS-2 Synthesis Exactly matched genes (5/12) include cps2B, cps2D, cps2F, cps2K, and cps2L and are shown in pink. The seven other genes (which did not exactly match) include cps2A cps2C, cps2E, cps2G, cps2H, cps2I, and cps2J and were highlighted with green in S. suis P1/7 and with red in both S. suis 98 and S. suis ZY. (cited from Plos medicine, May 2006. 3 (5 ):0668-0676)




Fig 2: The point variations in cps2A gene of Streptococcus suis strains

Fig 3: The point variations in cps2E gene of Streptococcus suis strains

Fig 4: The point variations in cps2G gene of Streptococcus suis strains


Fig 5: The point variations in cps2I gene of Streptococcus suis strains


S.suis
P 1/7

S.suis
SC84

S.suis
98HAH33

S.suis
05ZYH33

Fig 6 Comparison of the cps2 Gene Clusters Involved in CPS-2 Synthesis. The yellow represent this gene is dismatched with that of S.suis P 1/7. The white one means not exactly know.

No competing interests declared.