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Research Article

Serum Iron Levels and the Risk of Parkinson Disease: A Mendelian Randomization Study

  • Irene Pichler equal contributor mail,

    equal contributor Contributed equally to this work with: Irene Pichler, Fabiola Del Greco M.

    irene.pichler@eurac.edu (IP); cosetta.minelli@imperial.ac.uk (CM)

    Affiliation: Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom

    X
  • Fabiola Del Greco M. equal contributor,

    equal contributor Contributed equally to this work with: Irene Pichler, Fabiola Del Greco M.

    Affiliation: Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom

    X
  • Martin Gögele,

    Affiliation: Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom

    X
  • Christina M. Lill,

    Affiliations: Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany, Department of Neurology, Medical Center of the Johannes Gutenberg-University, Mainz, Germany

    X
  • Lars Bertram,

    Affiliation: Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany

    X
  • Chuong B. Do,

    Affiliation: 23andMe, Inc., Mountain View, California, United States of America

    X
  • Nicholas Eriksson,

    Affiliation: 23andMe, Inc., Mountain View, California, United States of America

    X
  • Tatiana Foroud,

    Affiliation: Indiana University School of Medicine, Indianapolis, Indiana, United States of America

    X
  • Richard H. Myers,

    Affiliation: Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

    X
  • PD GWAS Consortium,
  • Michael Nalls,

    Affiliation: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Margaux F. Keller,

    Affiliations: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America, Department of Biological Anthropology, Temple University, Philadelphia, Pennsylvania, United States of America

    X
  • International Parkinson's Disease Genomics Consortium,
  • Wellcome Trust Case Control Consortium 2,
  • Beben Benyamin,

    Affiliations: Queensland Institute of Medical Research, Brisbane, Queensland, Australia, Queensland Brain Institute, The University of Queensland, Queensland, Australia

    X
  • John B. Whitfield,

    Affiliation: Queensland Institute of Medical Research, Brisbane, Queensland, Australia

    X
  • Genetics of Iron Status Consortium,
  • Peter P. Pramstaller,

    Affiliations: Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom, Department of Neurology, General Central Hospital, Bolzano, Italy, Department of Neurology, University of Lübeck, Lübeck, Germany

    X
  • Andrew A. Hicks,

    Affiliation: Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom

    X
  • John R. Thompson,

    Affiliation: Department of Health Sciences, University of Leicester, Leicester, United Kingdom

    X
  • Cosetta Minelli mail

    irene.pichler@eurac.edu (IP); cosetta.minelli@imperial.ac.uk (CM)

    Affiliation: Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom

    X
  • Published: June 04, 2013
  • DOI: 10.1371/journal.pmed.1001462

Reader Comments (1)

Post a new comment on this article

Iron is needed in synthesis of Dopamin

Posted by frajow on 14 Jun 2013 at 11:09 GMT

The authors conclude:
Further studies are needed to understand the pathophysiological mechanism of action of serum iron on PD risk before recommendations can be made.
My point of view is:
The synthesis of Dopamin like other neurotransmitters needs iron, partly as iron containing enzymes , partly as coenzyme.
So it would be interesting to proofe, if high doses of intravenous applicated iron will improve symptoms, especially in case of iron deficiency.

No competing interests declared.