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Research in Translation

Research in Translation Research in Translation articles discuss a particular drug, treatment, or public health intervention in the context of translation from early research to clinical research, or clinical evidence to practice.

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The Genetics of Schizophrenia

  • Patrick F Sullivan
  • Published: July 26, 2005
  • DOI: 10.1371/journal.pmed.0020212

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Author response

Posted by plosmedicine on 30 Mar 2009 at 23:56 GMT

Author: Patrick Sullivan
Position: Professor
Institution: UNC/Genetics
E-mail: pfsulliv@med.unc.edu
Submitted Date: June 29, 2006
Published Date: July 3, 2006
This comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.

Jonathan Leo raises issues with the adoption literature on schizophrenia. These studies were intensively and independently scrutinized in the 1980s - see the series of papers by Kendler and Gruenberg (e.g., Arch Gen Psychiatry 1984;41:555-64). Most would agree that the number, size, and quality of adoption studies do not provide the highest quality data (as discussed at more length elsewhere (1).

However, the salient point in my paper was that this body of work (twin, adoption, and family studies) provide a consistent and solid rationale for the search for genes for schizophrenia.

Dr Leo's comments about the treatment of schizophrenia are not within the scope of my paper.

Reference
1. Sullivan PF, Owen MJ, O'Donovan MC, Freedman RR. Genetics. In: Lieberman J, Stroup T, Perkins D, editors. Textbook of Schizophrenia. Washington, DC: American Psychiatric Publishing, Inc.; 2005.

Competing interests declared: None