Research Article

Randomized, Controlled Intervention Trial of Male Circumcision for Reduction of HIV Infection Risk: The ANRS 1265 Trial

  • Bertran Auvert mail,

    To whom correspondence should be addressed. E-mail:

    Affiliations: Hôpital Ambroise-Paré, Assitance Publique—Hôpitaux de Paris, Boulogne, France, INSERM U 687, Saint-Maurice, France, University Versailles Saint-Quentin, Versailles, France, IFR 69, Villejuif, France

  • Dirk Taljaard,

    Affiliation: Progressus, Johannesburg, South Africa

  • Emmanuel Lagarde,

    Affiliations: INSERM U 687, Saint-Maurice, France, IFR 69, Villejuif, France

  • Joëlle Sobngwi-Tambekou,

    Affiliation: INSERM U 687, Saint-Maurice, France

  • Rémi Sitta,

    Affiliations: INSERM U 687, Saint-Maurice, France, IFR 69, Villejuif, France

  • Adrian Puren

    Affiliation: National Institute for Communicable Disease, Johannesburg, South Africa

  • Published: October 25, 2005
  • DOI: 10.1371/journal.pmed.0020298

Reader Comments (21)

Post a new comment on this article

Male circumcision and HIV in Africa

Posted by plosmedicine on 30 Mar 2009 at 23:46 GMT

Author: Taiwo Lawoyin
Position: Prof. of Community Medicine
Institution: College of Medicine, University College Hospital Ibadan, Nigeria.
Additional Authors: Kehinde OA
Submitted Date: October 26, 2005
Published Date: October 27, 2005
This comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.

We wish to congratulate the authors on their work and wish them more sucess in their endeavors.
Quite a number of studies have shown that circumcised males in heterosexual unions do have lower HIV rates (1-3). It would be good to know to what extent this circumcision status affects the HIV rates in subSaharan Africa countries presently bearing the brunt of the disease.
Though ecological studies are to be interpreted with caution, it would be interesting also to find out how this information helps us to understand better why some African countries with similar behavior have a much lower HIV rate than others (3-5). West African countries for example have significantly higher circumcision rates compared with countries in the Eastern and southern parts of Africa. HIV rates appear also to be generally lower in west Africa (6).
Also it would be interesting to find out if more African males who are not circumcised are ready to have this procedure done as a form of added protection as there seems to be pockets of resisitance to the procedure (7,8).

1. Agot KE et al. Risk of HIV-1 in rural Kenya: a comparison of circumcised men. Epidemiology 2004; 15(2): 157-163.
2. Siegfried N et al. HIV and male circumcision. A systematic review with assessment of the quality os studies. Lancet Infect Dis 2005; 5(3): 167-173.
3. Kehinde AO, Lawoyin TO, Bakare RA. Risk factors for HIV infection among special treatment clinic attendees in Ibadan Nigeria. Afr J Med and Med Sci 2004; 33(3): 229-34.
4. Elharti E et al. Some characteristics of HIV epidemics in Morocco. East Afr Med 2002; 8 (6): 819-25.
5. Mattson CL et al. Acceptability of male circumcision and predictors of circumcision prefernce among men and women in Nyanza province Kenya. AIDS Care 2005; 17(2): 182-94.
6. UNAIDS. Joint United Nations Program on HIV/AIDS. 2004 report on the global AIDs epidemic. Geneva.
7. No authors. Male circumcision as a preventive method? Study was controversial from day one. AIDS Alert 2005; 20(9): 101-2.
8. Alanis MC, Lucidi RS. Neonatal circumcision: a review of the worlds oldest and most controversial operation. Obs Gyn Sur 2004; 59(5): 379-95.

No competing interests declared.