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Essay

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Why Most Published Research Findings Are False

  • John P. A. Ioannidis
  • Published: August 30, 2005
  • DOI: 10.1371/journal.pmed.0020124

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Clinical trials on human subjects can never be definitively conclusive

Posted by plosmedicine on 30 Mar 2009 at 23:45 GMT

Author: Vijay Singh
Position: Doctor; government job
Institution: CCRH
E-mail: drvpsingh2004@hotmail.com
Submitted Date: September 01, 2005
Published Date: September 12, 2005
This comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.

Nothing surprising here about clinical trials. They continue to be as inclonclusive as they were in the last century. We need to realize that, where human beings are involved as research subjects and as investigators, there is every possibility of false perception, judgmental error and individual's own interest, which may be anything from fame to money. No wonder that recently there was a headline suggesting the most drugs do not do what they are meant to do. On the contrary some of them do just opposite. The practice of medicine is, as well as a science, an art. The same drug brings about different changes when prescribed by different physicians.

No competing interests declared.