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A Compendium of Potential Biomarkers of Pancreatic Cancer

  • H. C. Harsha,

    Affiliations: Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka, India, Manipal University, Manipal, Karnataka, India, McKusick-Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Kumaran Kandasamy,

    Affiliations: Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka, India, McKusick-Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Prathibha Ranganathan,

    Affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka, India

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  • Sandhya Rani,

    Affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka, India

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  • Subhashri Ramabadran,

    Affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka, India

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  • Sashikanth Gollapudi,

    Affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka, India

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  • Lavanya Balakrishnan,

    Affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka, India

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  • Sutopa B. Dwivedi,

    Affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka, India

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  • Deepthi Telikicherla,

    Affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka, India

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  • Lakshmi Dhevi N. Selvan,

    Affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka, India

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  • Renu Goel,

    Affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka, India

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  • Suresh Mathivanan,

    Affiliations: Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka, India, McKusick-Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Arivusudar Marimuthu,

    Affiliations: Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka, India, Manipal University, Manipal, Karnataka, India, McKusick-Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Manoj Kashyap,

    Affiliations: Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka, India, McKusick-Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Robert F. Vizza,

    Affiliation: The Lustgarten Foundation for Pancreatic Cancer Research, Bethpage, New York, United States of America

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  • Robert J. Mayer,

    Affiliation: Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • James A. DeCaprio,

    Affiliation: Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Sudhir Srivastava,

    Affiliation: Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Samir M. Hanash,

    Affiliation: Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Ralph H. Hruban,

    Affiliation: Departments of Pathology and Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institution, Baltimore, Maryland, United States of America

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  • Akhilesh Pandey mail

    pandey@jhmi.edu

    Affiliations: Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka, India, McKusick-Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, United States of America, Departments of Pathology and Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institution, Baltimore, Maryland, United States of America

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  • Published: April 07, 2009
  • DOI: 10.1371/journal.pmed.1000046

Reader Comments (2)

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Evidence for the need for a shift in priorities

Posted by clogsdon on 12 Aug 2009 at 22:52 GMT

This is an excellent compilation of potential biomarkers for pancreatic cancer. The authors should be congratulated for pulling together data from so many sources. As this work shows, the biggest difficulty at this point is that the list of candidates is so long.

Clearly the field is at a point where what is needed for pancreatic cancer isn't more candidates, but better ways to validate the candidates. The focus needs to shift from candidate discovery to biomarker validation.

We have been working to develop reverse phase array technology for rapid, inexpensive analysis of candidate biomarkers in patient samples (see PMID 18615426 ). This technology is promising, but needs further refinement. Other approaches that are high throughput are possible and should also be pursued.

For real progress on pancreatic cancer biomarkers cooperation will be needed from instutitions that have collections of appropriate blood samples. Comparisons between normal and cancer patients are not enough, chronic pancreatitis must be included. This type of multi-institutional cooperation will require leadership and financial backing. I would support some of these authors as potential leaders of such an effort.

No competing interests declared.