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Research Article

Randomized, Controlled Intervention Trial of Male Circumcision for Reduction of HIV Infection Risk: The ANRS 1265 Trial

  • Bertran Auvert mail,

    To whom correspondence should be addressed. E-mail: bertran.auvert@apr.aphp.fr

    Affiliations: Hôpital Ambroise-Paré, Assitance Publique—Hôpitaux de Paris, Boulogne, France, INSERM U 687, Saint-Maurice, France, University Versailles Saint-Quentin, Versailles, France, IFR 69, Villejuif, France

    X
  • Dirk Taljaard,

    Affiliation: Progressus, Johannesburg, South Africa

    X
  • Emmanuel Lagarde,

    Affiliations: INSERM U 687, Saint-Maurice, France, IFR 69, Villejuif, France

    X
  • Joëlle Sobngwi-Tambekou,

    Affiliation: INSERM U 687, Saint-Maurice, France

    X
  • Rémi Sitta,

    Affiliations: INSERM U 687, Saint-Maurice, France, IFR 69, Villejuif, France

    X
  • Adrian Puren

    Affiliation: National Institute for Communicable Disease, Johannesburg, South Africa

    X
  • Published: October 25, 2005
  • DOI: 10.1371/journal.pmed.0020298

Reader Comments (21)

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Rubbery figures?

Posted by plosmedicine on 30 Mar 2009 at 23:47 GMT

Author: Michael Glass
Position: Teacher
Institution: Department of Education & Training, NSW Australia
E-mail: mglass@mira.net
Submitted Date: October 29, 2005
Published Date: November 2, 2005
This comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.

Dear Editor:

I have been following reports of this study and have found four different figures for seroconversions.

The Abstract of the AIDS Conference in Rio reported 15 seroconversions from the circumcised group and 45 seroconversions in the uncircumcised group.

The New Scientist, 6 August, reported 15 seroconversions in the circumcised group but 51 in the uncircumcised group.

On 29 July the Science and Development Network reported 18 seroconversions in the circumcised group and 51 in the uncircumcised group.

Finally, on 23 October, PLOS reported that there were 20 seroconversions in the circumcised group and 49 in the uncircumcised group.

It seems passing strange that the figures should be so much at variance.

But if we just go from the official figures: 15-45 at the AIDS Conference in Brazil and 20-49 in the PLOS Journal, between 1 August and 23 October it would appear that there have been 4 seroconversions among the uncircumcised and 5 seroconversions among the circumcised. In less than 3 months, a 3:1 difference has shrunk to 2.45:1 difference.

Why are the numbers of seroconversions so much at variance in reports published by reputable journals?

Yours sincerely,

Michael Glass

No competing interests declared.