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Hypertrophic Scar Formation Following Burns and Trauma: New Approaches to Treatment

  • Shahram Aarabi,
  • Michael T Longaker,
  • Geoffrey C Gurtner mail

    To whom correspondence should be addressed. E-mail:

  • Published: September 04, 2007
  • DOI: 10.1371/journal.pmed.0040234

Reader Comments (2)

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burns stem cells and vessels

Posted by engrav on 14 May 2011 at 01:44 GMT

I enjoyed this paper, a very well done review of the many questions, fun read.

Question #1

"large traumatic skin defects (such as ... burn...) destroy the resident epidermal stem cell population and cannot be spontaneously regenerated."

Is it not true that
large but shallow burns and other tangential injuries leave the bulge intact and therefore the stem cells in the bulge? and this might be why shallow burns heal without hypertrophic scar? and so studies of the problem ought compare deep to shallow wounds, not deep wounds to normal skin?

Question #2

"…scars are highly vascular is at odds with the theory that hypoxia increases scar formation…"

Is it not true that
long long ago Kischer with EM demonstrated that many of the vessels are occluded and so many vessels and hypoxia might co-exist?

No competing interests declared.