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Defining Research to Improve Health Systems

  • Jan H. F. Remme,

    Affiliation: UNICEF/UNDP/World Bank/World Health Organization Special Programme for Research and Training in Tropical Diseases, Geneva, Switzerland

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  • Taghreed Adam,

    Affiliation: The Alliance for Health Policy and Systems Research, Geneva, Switzerland

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  • Francisco Becerra-Posada,

    Affiliation: Council on Health Research for Development, Mexico City, Mexico

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  • Catherine D'Arcangues,

    Affiliation: World Health Organization, Department of Reproductive Health and Research, Geneva, Switzerland

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  • Michael Devlin,

    Affiliation: Council on Health Research for Development, Geneva, Switzerland

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  • Charles Gardner,

    Affiliation: Global Forum for Health Research, Geneva, Switzerland

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  • Abdul Ghaffar,

    Affiliation: The Alliance for Health Policy and Systems Research, Geneva, Switzerland

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  • Joachim Hombach,

    Affiliation: World Health Organization, Initiative for Vaccine Research, Geneva, Switzerland

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  • Jane F. K. Kengeya,

    Affiliation: UNICEF/UNDP/World Bank/World Health Organization Special Programme for Research and Training in Tropical Diseases, Geneva, Switzerland

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  • Anthony Mbewu,

    Affiliation: Global Forum for Health Research, Geneva, Switzerland

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  • Michael T. Mbizvo,

    Affiliation: World Health Organization, Department of Reproductive Health and Research, Geneva, Switzerland

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  • Zafar Mirza,

    Affiliation: World Health Organization, Department of Public Health, Innovation and Intellectual Property, Geneva, Switzerland

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  • Tikki Pang,

    Affiliation: World Health Organization, Department of Research Policy and Cooperation, Geneva, Switzerland

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  • Robert G. Ridley,

    Affiliation: UNICEF/UNDP/World Bank/World Health Organization Special Programme for Research and Training in Tropical Diseases, Geneva, Switzerland

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  • Fabio Zicker,

    Affiliation: UNICEF/UNDP/World Bank/World Health Organization Special Programme for Research and Training in Tropical Diseases, Geneva, Switzerland

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  • Robert F. Terry mail

    terryr@who.int

    Affiliation: World Health Organization, Department of Research Policy and Cooperation, Geneva, Switzerland

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  • Published: November 16, 2010
  • DOI: 10.1371/journal.pmed.1001000
  • Featured in PLOS Collections

Reader Comments (1)

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Implementational research and clinical trials

Posted by peterbyass on 22 Nov 2010 at 14:18 GMT

Implementation research aims to develop strategies for available or new health interventions in order to improve access to, and the use of, these interventions by the populations in need.
http://plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001000#article1.body1.sec2.sec2.p1

Thanks for this interesting article. I think there is a further aspect here that perhaps deserves exploration - the question of when implementational research becomes a clinical trial? If, for example, a local health authority decides to deliver a particular drug treatment in different ways in two different districts, and then investigate the outcomes, is that something that should conform to ICMJE and Consort guidelines for clinical trials, and which must therefore be pre-registered as such in order to be published? I suspect there is something of a grey area here.

Competing interests declared: PLoS Med editorial board