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Research Article

Randomized, Controlled Intervention Trial of Male Circumcision for Reduction of HIV Infection Risk: The ANRS 1265 Trial

  • Bertran Auvert mail,

    To whom correspondence should be addressed. E-mail: bertran.auvert@apr.aphp.fr

    Affiliations: Hôpital Ambroise-Paré, Assitance Publique—Hôpitaux de Paris, Boulogne, France, INSERM U 687, Saint-Maurice, France, University Versailles Saint-Quentin, Versailles, France, IFR 69, Villejuif, France

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  • Dirk Taljaard,

    Affiliation: Progressus, Johannesburg, South Africa

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  • Emmanuel Lagarde,

    Affiliations: INSERM U 687, Saint-Maurice, France, IFR 69, Villejuif, France

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  • Joëlle Sobngwi-Tambekou,

    Affiliation: INSERM U 687, Saint-Maurice, France

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  • Rémi Sitta,

    Affiliations: INSERM U 687, Saint-Maurice, France, IFR 69, Villejuif, France

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  • Adrian Puren

    Affiliation: National Institute for Communicable Disease, Johannesburg, South Africa

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  • Published: October 25, 2005
  • DOI: 10.1371/journal.pmed.0020298

Reader Comments (21)

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Male circumcision increases risk for females

Posted by plosmedicine on 30 Mar 2009 at 23:48 GMT

Author: Jonathan Sykes
Position: Mr./Independent Researcher
Institution: Self-employed
E-mail: jsykes30@earthlink.net
Submitted Date: November 24, 2005
Published Date: November 25, 2005
This comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.

Dear Editor:

Auvert et al. argue that male circumcision provides a protective effect for males.[1] On the other hand, Chao et al. identified circumcision of the male partner as a risk factor for females.[2] Auvert et al. do not provide information on the overall effect of male circumcision on HIV transmission and infection.[1] Male circumcision may worsen the epidemic. It is imperative, therefore, that further studies be conducted to determine the overall effect before implementation of mass circumcision campaigns to control HIV infection.

Jonathan Sykes

References

1. Auvert B, Taljaard D, Lagarde E, Sobngwi-Tambekou J, Sitta R, et al. (2005)
Randomized, Controlled Intervention Trial of Male Circumcision for Reduction of HIV
Infection Risk: The ANRS 1265 Trial. PLoS Med 2(11): e2

2. Chao A, Bulterys M, Musanganire F, et al. Risk factors associated with prevalent HIV-1 infection among pregnant women in Rwanda. National University of Rwanda-Johns Hopkins University AIDS Research Team. Int J Epidemiol 1994; 23(2):371-80. [ http://www.ncbi.nlm.nih.g... ]

No competing interests declared.