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Research Article

Blood Glucose and Risk of Incident and Fatal Cancer in the Metabolic Syndrome and Cancer Project (Me-Can): Analysis of Six Prospective Cohorts

  • Tanja Stocks mail,

    tanja.stocks@urologi.umu.se

    Affiliation: Department of Surgical and Perioperative sciences, Urology and Andrology, Umeå University, Umeå, Sweden

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  • Kilian Rapp,

    Affiliation: Institute of Epidemiology, Ulm University, Ulm, Germany

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  • Tone Bjørge,

    Affiliations: Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway, Norwegian Institute of Public Health, Bergen, Norway

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  • Jonas Manjer,

    Affiliation: Department of Surgery, Malmö University Hospital, Malmö, Sweden

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  • Hanno Ulmer,

    Affiliation: Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck, Austria

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  • Randi Selmer,

    Affiliation: Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway

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  • Annekatrin Lukanova,

    Affiliation: Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany

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  • Dorthe Johansen,

    Affiliation: Department of Surgery, Malmö University Hospital, Malmö, Sweden

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  • Hans Concin,

    Affiliation: Agency for Preventive and Social Medicine, Bregenz, Austria

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  • Steinar Tretli,

    Affiliation: Institute of Population-based Cancer Research, The Cancer Registry of Norway, Oslo, Norway

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  • Göran Hallmans,

    Affiliation: Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Sweden

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  • Håkan Jonsson,

    Affiliation: Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden

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  • Pär Stattin

    Affiliation: Department of Surgical and Perioperative sciences, Urology and Andrology, Umeå University, Umeå, Sweden

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  • Published: December 22, 2009
  • DOI: 10.1371/journal.pmed.1000201

Reader Comments (1)

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The association between blood glucose and fetal cancer, not enough data to adress the causality question

Posted by gwdlandman on 23 Jan 2010 at 16:03 GMT

The author’s state that the link between blood glucose and cancer may be causal but acknowledge that there may be confounding involved for which they did not correct. However they do not mention one important and recently recognized confounder; glucose lowering therapy itself [1]. Glucose lowering therapy is associated with fasting glucose levels and is also associated with cancer mortality. It might be better not to address the question about causality in absence of data on important confounders.


1.Landman GW, Kleefstra N, van Hateren KJ, Groenier KH, Gans RO, Bilo HJ. Metformin associated with lower cancer mortality in type 2 diabetes (ZODIAC-16). Diabetes Care. 2009 Nov 16. [Epub ahead of print]

No competing interests declared.