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Research Article

Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak

  • Isabelle Schuffenecker mail,

    To whom correspondence should be addressed. E-mail: schuffenecker@cervi-lyon.inserm.fr (IS); E-mail: sbrisse@pasteur.fr (SB)

    Affiliation: Centre National de Référence des Arbovirus, Institut Pasteur, Lyon, France

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  • Isabelle Iteman,

    Affiliation: Plate-forme Génotypage des Pathogènes et Santé Publique (PF8), Institut Pasteur, Paris, France

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  • Alain Michault,

    Affiliation: Laboratoire de Microbiologie, Hôpital St Pierre, St Pierre, Ile de la Réunion, France

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  • Séverine Murri,

    Affiliation: Centre National de Référence des Arbovirus, Institut Pasteur, Lyon, France

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  • Lionel Frangeul,

    Affiliation: Plate-forme Intégration et Analyse Génomique, Institut Pasteur, Paris, France

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  • Marie-Christine Vaney,

    Affiliations: Unité de Virologie Structurale, Institut Pasteur, Paris, France, Centre National de la Recherche Scientifique/Institut National de la Recherche Agronomique UMR 2472/1157, Paris, France

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  • Rachel Lavenir,

    Affiliation: Plate-forme Génotypage des Pathogènes et Santé Publique (PF8), Institut Pasteur, Paris, France

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  • Nathalie Pardigon,

    Affiliation: Unité des Interactions Moléculaires Flavivirus-Hôtes, Institut Pasteur, Paris, France

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  • Jean-Marc Reynes,

    Affiliation: Unité de Virologie, Institut Pasteur, Antananarivo, Madagascar

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  • François Pettinelli,

    Affiliation: Laboratoire de Biologie Médicale, Centre Hospitalier de Mayotte, Mamoudzou, Mayotte, France

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  • Leon Biscornet,

    Affiliation: Disease Surveillance and Sexually Transmitted Infections Unit, Seychelles Public Health Laboratory, Ministry of Health and Social Services, Victoria, Mahe, Seychelles

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  • Laure Diancourt,

    Affiliation: Plate-forme Génotypage des Pathogènes et Santé Publique (PF8), Institut Pasteur, Paris, France

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  • Stéphanie Michel,

    Affiliation: Centre National de Référence des Arbovirus, Institut Pasteur, Lyon, France

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  • Stéphane Duquerroy,

    Affiliations: Unité de Virologie Structurale, Institut Pasteur, Paris, France, Centre National de la Recherche Scientifique/Institut National de la Recherche Agronomique UMR 2472/1157, Paris, France, Université Paris, XI-Orsay, Paris, France

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  • Ghislaine Guigon,

    Affiliation: Plate-forme Génotypage des Pathogènes et Santé Publique (PF8), Institut Pasteur, Paris, France

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  • Marie-Pascale Frenkiel,

    Affiliation: Unité des Interactions Moléculaires Flavivirus-Hôtes, Institut Pasteur, Paris, France

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  • Anne-Claire Bréhin,

    Affiliation: Unité des Interactions Moléculaires Flavivirus-Hôtes, Institut Pasteur, Paris, France

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  • Nadège Cubito,

    Affiliation: Centre National de Référence des Arbovirus, Institut Pasteur, Lyon, France

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  • Philippe Desprès,

    Affiliation: Unité des Interactions Moléculaires Flavivirus-Hôtes, Institut Pasteur, Paris, France

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  • Frank Kunst,

    Affiliation: Unité de Génomique des Microorganismes Pathogènes and Centre National de la Recherche Scientifique URA 2171, Institut Pasteur, Paris, France

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  • Félix A Rey,

    Affiliations: Unité de Virologie Structurale, Institut Pasteur, Paris, France, Centre National de la Recherche Scientifique URA 1930, Paris, France

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  • Hervé Zeller,

    Affiliation: Centre National de Référence des Arbovirus, Institut Pasteur, Lyon, France

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  • Sylvain Brisse mail

    To whom correspondence should be addressed. E-mail: schuffenecker@cervi-lyon.inserm.fr (IS); E-mail: sbrisse@pasteur.fr (SB)

    Affiliation: Plate-forme Génotypage des Pathogènes et Santé Publique (PF8), Institut Pasteur, Paris, France

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  • Published: May 23, 2006
  • DOI: 10.1371/journal.pmed.0030263

Reader Comments (1)

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Chikungunya Virus: Additional Diagnostic Aid

Posted by plosmedicine on 30 Mar 2009 at 23:55 GMT

Author: Jairaj C. Kumar
Position: Visiting Research Fellow
Institution: J.N.Center for Advanced Scientific Research, Bangalore
E-mail: ixedoc@hotmail.com
Additional Authors: Arunachalam Kumar, K S Hegde Medical Academy, Mangalore
Submitted Date: May 25, 2006
Published Date: June 1, 2006
This comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.

In this part of the third world, the rural reaches of interior rural India, the priority remains on early diagnosis and rapid hospitalization of the Chikungunya afflicted patient. In recent weeks thousands of patients in south India have flocked into city-based hospitals for treatment, throwing the already overstrained medical services into a flux. In most cases diagnosis has often been delayed, missed, or confused by tertiary level clinicians.

The authors cite the disease - as an acute infection of abrupt onset, characterized by high fever, arthralgia, myalgia, headache, and rash. Poly-arthralgia, the typical clinical sign of the disease, is very painful. Symptoms are generally self-limiting. However, arthralgia may persist for months or years. In some patients, minor hemorrhagic signs such as epistaxis or gingivorrhagia have also been described.

In our ongoing study being conducted at two locales in two worst affected southern states, we have found that in establishing the diagnosis at grassroots level, apart from the cited confirmatory signs and symptoms, one more minor yet invariably mentioned problem is terrorizing nightmares. All eight patients referred to hospital for the virus gave a history of dreadful dreams and disturbing nighmares.
We report this as a possible diagnostic feature for Chikungunya Virus.

No competing interests declared.