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Research Article

Assessment of Volume Depletion in Children with Malaria

  • Timothy Planche,

    Affiliations: Department of Cellular and Molecular Medicine, Infectious Diseases, St. George's Hospital Medical School, London, United Kingdom, Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon

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  • Myriam Onanga,

    Affiliation: Département de Parasitologie, Mycologie, et Médecine Tropicale, Faculté de Médecine, Université des Sciences de la Santé, Libreville, Gabon

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  • Achim Schwenk,

    Affiliations: Department of Cellular and Molecular Medicine, Infectious Diseases, St. George's Hospital Medical School, London, United Kingdom, Coleridge Unit, North Middlesex University Hospital, London, United Kingdom

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  • Arnaud Dzeing,

    Affiliation: Département de Parasitologie, Mycologie, et Médecine Tropicale, Faculté de Médecine, Université des Sciences de la Santé, Libreville, Gabon

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  • Steffen Borrmann,

    Affiliations: Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon, Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany

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  • Jean-François Faucher,

    Affiliation: Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon

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  • Antony Wright,

    Affiliation: Elsie Widdowson Laboratory, Medical Research Council Human Nutrition Research, Cambridge, United Kingdom

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  • Les Bluck,

    Affiliation: Elsie Widdowson Laboratory, Medical Research Council Human Nutrition Research, Cambridge, United Kingdom

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  • Leigh Ward,

    Affiliation: Department of Biochemistry, University of Queensland, St Lucia, Australia

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  • Maryvonne Kombila,

    Affiliation: Département de Parasitologie, Mycologie, et Médecine Tropicale, Faculté de Médecine, Université des Sciences de la Santé, Libreville, Gabon

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  • Peter G Kremsner,

    Affiliations: Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon, Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany

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  • Sanjeev Krishna

    Affiliations: Department of Cellular and Molecular Medicine, Infectious Diseases, St. George's Hospital Medical School, London, United Kingdom, Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon

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  • Published: October 19, 2004
  • DOI: 10.1371/journal.pmed.0010018

Reader Comments (2)

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Reply to Maitland et al

Posted by plosmedicine on 30 Mar 2009 at 23:38 GMT

Author: Sanjeev Krishna
Position: Professor
Institution: St. George's Hospital Medical School
E-mail: s.krishna@sghms.ac.uk
Additional Authors: Dr. Tim Planche
Submitted Date: November 20, 2004
Published Date: November 22, 2004
This comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.

Dear Editor,

We are pleased that Dr. Maitland and colleagues consider our data on volume status (intra- and extra-cellular) of Gabonese children to be important. We did not consider our children with severe malaria to have intravascular volume depletion for the following reasons. When we measured central venous pressures in a proportion of children on admission, there was no evidence of intravascular volume depletion (median (interquartile range) = 6.5 (3-7.5) cm water), and these values did not change significantly over 24 h, suggesting that our severely ill children had adequate filling pressures. Consistent with this observation, our severely ill children improved rapidly when markers of tissue hypoxia (blood lactate concentrations, tachycardia and tachypnoea) were serially monitored and children were managed with a relatively conservative fluid replacement regimen. Interestingly, extracellular volume was not increased at admission or afterwards either. Capillary leakage, which commonly accompanies hypovolaemia associated with septic shock, was therefore unlikely to be a significant pathophysiological process in these children with malaria.
There may be differences in the severe syndromes of malaria seen in different geographical locations, perhaps accounting for the clinical features attributable to compensated hypovolemic shock reported by Maitland and colleagues. Such differences can be assessed using simple and recently calibrated BIA methodology as well as other techniques that monitor intravascular volumes. The design of optimal fluid management regimens for children with severe malaria can thus be informed not only by theoretical considerations, but also by appropriate physiological assessments.

Dr. Tim Planche
Professor Sanjeev Krishna

No competing interests declared.