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Research Article

Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration

  • Irving Kirsch mail,

    To whom correspondence should be addressed. E-mail: i.kirsch@hull.ac.uk

    Affiliation: Department of Psychology, University of Hull, Hull, United Kingdom

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  • Brett J Deacon,

    Affiliation: University of Wyoming, Laramie, Wyoming, United States of America

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  • Tania B Huedo-Medina,

    Affiliation: Center for Health, Intervention, and Prevention, University of Connecticut, Storrs, Connecticut, United States of America

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  • Alan Scoboria,

    Affiliation: Department of Psychology, University of Windsor, Windsor, Ontario, Canada

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  • Thomas J Moore,

    Affiliation: Institute for Safe Medication Practices, Huntingdon Valley, Pennsylvania, United States of America

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  • Blair T Johnson

    Affiliation: Center for Health, Intervention, and Prevention, University of Connecticut, Storrs, Connecticut, United States of America

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  • Published: February 26, 2008
  • DOI: 10.1371/journal.pmed.0050045

Reader Comments (48)

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Using this for a psych paper

Posted by FadieGhraib on 08 Aug 2011 at 00:07 GMT

Additional analyses indicated that the apparent clinical
effectiveness of the antidepressants among these most severely depressed patients
reflected a decreased responsiveness to placebo rather than an increased responsiveness
to antidepressants.

http://plosmedicine.org/article/info:doi/10.1371/journal.pmed.0050045#article1.front1.article-meta1.abstract3.sec3.p1

Using this as a direct quote for a paper I am writing.

No competing interests declared.