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Research Article

Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass Index

  • Shahrad Taheri,

    Affiliation: Howard Hughes Medical Institute, Stanford University, Palo Alto, California, United States of America

    ¤Current address: Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, United Kingdom

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  • Ling Lin,

    Affiliation: Howard Hughes Medical Institute, Stanford University, Palo Alto, California, United States of America

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  • Diane Austin,

    Affiliation: Department of Population Health Sciences, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Terry Young,

    Affiliation: Department of Population Health Sciences, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Emmanuel Mignot mail

    To whom correspondence should be addressed. E-mail: mignot@stanford.edu

    Affiliation: Howard Hughes Medical Institute, Stanford University, Palo Alto, California, United States of America

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  • Published: December 07, 2004
  • DOI: 10.1371/journal.pmed.0010062

Reader Comments (1)

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This Involves Melatonin and DHEA

Posted by plosmedicine on 30 Mar 2009 at 23:39 GMT

Author: James Howard
Position: biologist
Institution: independent
E-mail: jmhoward@anthropogeny.com
Submitted Date: January 07, 2005
Published Date: January 10, 2005
This comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.

It is my hypothesis of sleep is that melatonin is high at night and DHEA is high during the day. One affects the production of the other. If melatonin is low, then DHEA is low. Taheri reported "Participants with short sleep had reduced leptin and elevated ghrelin." I suggest their findings may indicate that melatonin may be low in their subjects and this is connected with their findings. Melatonin decreases leptin (Endocrine. 2003 Jul;21(2):169-73) and increases ghrelin (Endocrine. 2001 Oct;16(1):43-6).

Now, I suggest this reduced production of melatonin and, therefore, DHEA may be the cause of increased BMI in their subjects. DHEA is known to reduce fat / obesity.

No competing interests declared.