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Research Article

Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration

  • Irving Kirsch mail,

    To whom correspondence should be addressed. E-mail: i.kirsch@hull.ac.uk

    Affiliation: Department of Psychology, University of Hull, Hull, United Kingdom

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  • Brett J Deacon,

    Affiliation: University of Wyoming, Laramie, Wyoming, United States of America

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  • Tania B Huedo-Medina,

    Affiliation: Center for Health, Intervention, and Prevention, University of Connecticut, Storrs, Connecticut, United States of America

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  • Alan Scoboria,

    Affiliation: Department of Psychology, University of Windsor, Windsor, Ontario, Canada

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  • Thomas J Moore,

    Affiliation: Institute for Safe Medication Practices, Huntingdon Valley, Pennsylvania, United States of America

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  • Blair T Johnson

    Affiliation: Center for Health, Intervention, and Prevention, University of Connecticut, Storrs, Connecticut, United States of America

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  • Published: February 26, 2008
  • DOI: 10.1371/journal.pmed.0050045

Reader Comments (48)

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naive and ignorant

Posted by plosmedicine on 31 Mar 2009 at 00:21 GMT

Author: Ricardo Vargas
Position: Family Physician
Institution: Lakeside Primary Care
E-mail: rvargas@novanthealth.org
Submitted Date: February 26, 2008
Published Date: February 27, 2008
This comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.

Any competent physician who has any experience treating depression will completely disagree with the findings of your "analysis" regarding antidepressants.
This gathering of data is done in a scientific way but it is far from perfect.
Doctors and patients know what works and what does not. I can assure you that antidepressants work very well for all severities of depression and if you stand by the findings of your paper then you are naive and ignorant.

No competing interests declared.