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Research Article

Effects on Coronary Heart Disease of Increasing Polyunsaturated Fat in Place of Saturated Fat: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

  • Dariush Mozaffarian mail,

    dmozaffa@hsph.harvard.edu

    Affiliations: Division of Cardiovascular Medicine and Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Renata Micha,

    Affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Sarah Wallace

    Affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Published: March 23, 2010
  • DOI: 10.1371/journal.pmed.1000252

Reader Comments (7)

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Confused

Posted by m2gym on 07 Jun 2010 at 00:13 GMT

The discussion points out that: "...the present findings _cannot_ distinguish between potentially distinct benefits of increasing PUFA versus decreasing SFA. Thus, the present evidence alone is _insufficient_ to conclude that _increasing_ PUFA in place of any other nutrient will reduce CHD events." Yet your conclusion is: "These findings provide evidence that consuming PUFA _in place of_ SFA reduces CHD events in RCTs."

No competing interests declared.