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Research Article

Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration

  • Irving Kirsch mail,

    To whom correspondence should be addressed. E-mail: i.kirsch@hull.ac.uk

    Affiliation: Department of Psychology, University of Hull, Hull, United Kingdom

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  • Brett J Deacon,

    Affiliation: University of Wyoming, Laramie, Wyoming, United States of America

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  • Tania B Huedo-Medina,

    Affiliation: Center for Health, Intervention, and Prevention, University of Connecticut, Storrs, Connecticut, United States of America

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  • Alan Scoboria,

    Affiliation: Department of Psychology, University of Windsor, Windsor, Ontario, Canada

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  • Thomas J Moore,

    Affiliation: Institute for Safe Medication Practices, Huntingdon Valley, Pennsylvania, United States of America

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  • Blair T Johnson

    Affiliation: Center for Health, Intervention, and Prevention, University of Connecticut, Storrs, Connecticut, United States of America

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  • Published: February 26, 2008
  • DOI: 10.1371/journal.pmed.0050045

Reader Comments (48)

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Antidepressants and me

Posted by plosmedicine on 31 Mar 2009 at 00:20 GMT

Author: Denis Thirlwell
Position: Fitter/Linesetter
Institution: Factory worker
E-mail: ddthirlwell@optusnet.com.au
Submitted Date: February 26, 2008
Published Date: February 27, 2008
This comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.

I have been suffering depression , OCD and Panic attacks in different degrees of severity for 25 yrs and have found Aropax (Paroxetine) a most valuable drug in relieving the mental pain and anxiety you can suffer as a result of this form of mental illness.
If not for this drug and the occasional use of Xanax,I would not have been able to remain in the workforce for any length of time.
In the early stages of my first major depression,I recieved intensive psychiatric councelling in a Sydney hospital and have been able to lead a "relativily normal" life since,but with constant fear of another depressive episode. without a rigorous set of "routines", I would not get through the day.
I hope my story is of some help

No competing interests declared.