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Research Article

Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration

  • Irving Kirsch mail,

    To whom correspondence should be addressed. E-mail: i.kirsch@hull.ac.uk

    Affiliation: Department of Psychology, University of Hull, Hull, United Kingdom

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  • Brett J Deacon,

    Affiliation: University of Wyoming, Laramie, Wyoming, United States of America

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  • Tania B Huedo-Medina,

    Affiliation: Center for Health, Intervention, and Prevention, University of Connecticut, Storrs, Connecticut, United States of America

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  • Alan Scoboria,

    Affiliation: Department of Psychology, University of Windsor, Windsor, Ontario, Canada

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  • Thomas J Moore,

    Affiliation: Institute for Safe Medication Practices, Huntingdon Valley, Pennsylvania, United States of America

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  • Blair T Johnson

    Affiliation: Center for Health, Intervention, and Prevention, University of Connecticut, Storrs, Connecticut, United States of America

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  • Published: February 26, 2008
  • DOI: 10.1371/journal.pmed.0050045

Reader Comments (48)

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These are not all SSRIs

Posted by plosmedicine on 31 Mar 2009 at 00:21 GMT

Author: Andrew Watson
Position: ST3 in Psychiatry
Institution: NHS Forth Valley
E-mail: drandrewatson@hotmail.com
Submitted Date: February 26, 2008
Published Date: February 27, 2008
This comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.

Venlafaxine is not an SSRI; it is serotonin-norepinephrine reuptake inhibitor.
Nefazodone has complex serotonin and norepinephrine agonist properties and very mild reuptake inhibition.

Looking at table one the mean changes for nefazodone appear to be much closer to placebo than the other drugs examined. It would more clinically relevent to see these drugs, which have different mechanisms and speed of action, presented separately.

No competing interests declared.