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Research in Translation

Research in Translation Research in Translation articles discuss a particular drug, treatment, or public health intervention in the context of translation from early research to clinical research, or clinical evidence to practice.

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Graft-Versus-Host Disease: A Surge of Developments

  • Stanley R Riddell,
  • Frederick R Appelbaum mail

    To whom correspondence should be addressed. E-mail: fappelba@fhcrc.org

    X
  • Published: July 10, 2007
  • DOI: 10.1371/journal.pmed.0040198

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How about CD8+ minor histocompatibility antigen-specific cytotoxic T lymphocyte clones use without a prior immun ablation?

Posted by plosmedicine on 31 Mar 2009 at 00:11 GMT

Author: Alexis Cochino
Position: pediatrics resident
Institution: IOMC
E-mail: alexis_virgil@yahoo.com
Submitted Date: August 04, 2007
Published Date: August 6, 2007
This comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.

Hello! Thank you for the very interesting paper!

Not being a specialist in this topic, my question might sound foolish, but I wonder, could CD8+ minor histocompatibility antigen-specific cytotoxic T lymphocyte clones be used as treatment in leukemia WITHOUT a prior ablative treatment? Has that been tried? Maybe with SOME immune supression but not ablative regimens, followed by these clones' infusion and, afterwards, SELF immune system reconstitution (with/without growing factors).

It would be very nice and it would save us from worrying about GVHD.

Thank you very much!

No competing interests declared.