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Fever, Headache, and Visual Blurring in a 17-Year-Old Woman

  • William Lynn,
  • Sue Lightman
  • Published: October 19, 2004
  • DOI: 10.1371/journal.pmed.0010007

Reader Comments (4)

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Hypoglycorrhachia--an underdiagnosed etiology

Posted by plosmedicine on 30 Mar 2009 at 23:38 GMT

Author: leslie barton
Position: Prof of Pediatrics
Institution: University of AZ School of Medicine
E-mail: llb@peds.arizona.edu
Submitted Date: November 04, 2004
Published Date: November 9, 2004
This comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.

I read with great interest the case report of Lynn and Lightman of a young woman with Vogt-Koyanagi-Harada syndrome. I must, however, quibble with the authors' assertion that mumps is the only viral etiology of meningitis that is "consistently associated with reduced CSF glucose." Lymphocytic choriomeningitis virus(LCMV)-associated meningitis is frequently associated with both cerebrospinal fluid(CSF) pleocytosis as well as decreased CSF glucose.(1,2) LCMV, a rodent-borne arenavirus, remains an underdiagnosed CNS pathogen productive of a broad spectrum of neuropathology.

References:
1.Green WR, Sweet LK, Prichard RW. Acute lymphocytic choriomeningitis virus meningitis. J Pediatr 1949;35:688-701.
2.Barton LL, Hyndman NJ. Lymphocytic choriomeningitis virus: Reemerging central nervous system pathogen. Pediatrics 2000;105(3):e35.

No competing interests declared.